Lecce gewann die Serie B 2021-22 mit 71 Punkten.
| 10 |
| 9 |
| 60 |
| 38 |
| +22 |
| SUNSN |
| 5 |  Brescia | 66 | 38 | 17 | 15 | 6 | 55 | 35 | +20 | SUUNS |
| 6 |  Ascoli | 65 | 38 | 19 | 8 | 11 | 52 | 42 | +10 | SSUSS |
| 7 |  Benevento | 63 | 38 | 18 | 9 | 11 | 62 | 39 | +23 | NSNNN |
| 8 |  Perugia | 58 | 38 | 14 | 16 | 8 | 40 | 32 | +8 | USSNS |
| 9 |  Frosinone | 58 | 38 | 15 | 13 | 10 | 58 | 45 | +13 | SUSNN |
| 10 |  Ternana | 54 | 38 | 15 | 9 | 14 | 58 | 61 | -3 | SUSSN |
| 11 |  Cittadella | 52 | 38 | 13 | 13 | 12 | 38 | 36 | +2 | SNUSN |
| 12 |  Parma | 49 | 38 | 11 | 16 | 11 | 48 | 43 | +5 | NNNUS |
| 13 |  como | 47 | 38 | 11 | 14 | 13 | 49 | 54 | -5 | NNNSN |
| 14 |  Reggina | 46 | 38 | 13 | 9 | 16 | 31 | 49 | -18 | NSUNN |
| 15 |  SPAL | 42 | 38 | 9 | 15 | 14 | 46 | 54 | -8 | NUUSS |
| 16 |  Nuova Cosenza | 35 | 38 | 8 | 11 | 19 | 36 | 59 | -23 | SNSUS |
| 17 |  Vicenza Virtus | 34 | 38 | 9 | 7 | 22 | 38 | 59 | -21 | NNSSS |
| 18 |  Alessandria | 34 | 38 | 8 | 10 | 20 | 37 | 59 | -22 | SSUUN |
| 19 |  Crotone | 26 | 38 | 4 | 14 | 20 | 41 | 61 | -20 | NUSUN |
| 20 |  Pordenone | 18 | 38 | 3 | 9 | 26 | 29 | 71 | -42 | NNNUN |
