Empoli won the 2020-21 Serie B with 73 points.
| # | Team | Pts | P | W | D | L | GF | GA | GD | Last 5 |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Empoli | 73 | 38 | 19 | 16 | 3 | 68 | 35 | +33 | DLWLW |
| 2 |  Salernitana | 69 | 38 | 19 | 12 | 7 | 46 | 34 | +12 | WLWWW |
| 3 |  Monza | 64 | 38 | 17 | 13 | 8 | 51 | 33 | +18 | WWWWL |
| 4 |  Lecce | 62 | 38 | 16 | 14 |
| 8 |
| 68 |
| 47 |
| +21 |
| WLLDL |
| 5 |  Venezia | 59 | 38 | 15 | 14 | 9 | 53 | 39 | +14 | LWDDD |
| 6 |  Cittadella | 57 | 38 | 15 | 12 | 11 | 48 | 35 | +13 | WWWLD |
| 7 |  Brescia | 56 | 38 | 15 | 11 | 12 | 61 | 53 | +8 | LWWWW |
| 8 |  Chievo | 56 | 38 | 14 | 14 | 10 | 50 | 37 | +13 | DLDWW |
| 9 |  SPAL | 56 | 38 | 14 | 14 | 10 | 44 | 42 | +2 | LLLWW |
| 10 |  Frosinone | 50 | 38 | 12 | 14 | 12 | 38 | 42 | -4 | LWWDW |
| 11 |  Reggina | 50 | 38 | 12 | 14 | 12 | 42 | 45 | -3 | WDDDL |
| 12 |  Vicenza Virtus | 48 | 38 | 11 | 15 | 12 | 48 | 53 | -5 | LWLDW |
| 13 |  Cremonese | 48 | 38 | 12 | 12 | 14 | 46 | 44 | +2 | LDDWL |
| 14 |  Pisa | 48 | 38 | 11 | 15 | 12 | 54 | 59 | -5 | DLDLW |
| 15 |  Pordenone | 45 | 38 | 10 | 15 | 13 | 40 | 39 | +1 | DLLDW |
| 16 |  Ascoli | 44 | 38 | 11 | 11 | 16 | 37 | 48 | -11 | WWDWL |
| 17 |  Nuova Cosenza | 35 | 38 | 6 | 17 | 15 | 29 | 47 | -18 | LWLLL |
| 18 |  Reggiana | 34 | 38 | 9 | 7 | 22 | 31 | 57 | -26 | LWLLL |
| 19 |  Pescara | 32 | 38 | 7 | 11 | 20 | 29 | 60 | -31 | DLWLL |
| 20 |  Virtus Entella | 23 | 38 | 4 | 11 | 23 | 30 | 64 | -34 | DLLLL |