Espanyol a remporté la Segunda División 2020-21 avec 82 points.
| 10 |
| 11 |
| 61 |
| 40 |
| +21 |
| VNDVV |
| 5 |  Girona | 71 | 42 | 20 | 11 | 11 | 47 | 36 | +11 | VVVVN |
| 6 |  Rayo Vallecano | 67 | 42 | 19 | 10 | 13 | 52 | 40 | +12 | NVVVD |
| 7 |  Sporting Gijon | 65 | 42 | 17 | 14 | 11 | 37 | 28 | +9 | VDVND |
| 8 |  Ponferradina | 57 | 42 | 15 | 12 | 15 | 45 | 50 | -5 | DVDDN |
| 9 |  Las Palmas | 56 | 42 | 14 | 14 | 14 | 46 | 53 | -7 | NDDVV |
| 10 |  Mirandes | 54 | 42 | 14 | 12 | 16 | 38 | 41 | -3 | VDNND |
| 11 |  Fuenlabrada | 54 | 42 | 12 | 18 | 12 | 45 | 46 | -1 | DDDNV |
| 12 |  Malaga | 53 | 42 | 14 | 11 | 17 | 37 | 47 | -10 | NDDDV |
| 13 |  Oviedo | 52 | 42 | 11 | 19 | 12 | 45 | 46 | -1 | VVDNN |
| 14 |  Tenerife | 52 | 42 | 13 | 13 | 16 | 36 | 36 | 0 | DVDNN |
| 15 |  Zaragoza | 50 | 42 | 13 | 11 | 18 | 37 | 43 | -6 | NVVDD |
| 16 |  FC Cartagena | 49 | 42 | 12 | 13 | 17 | 44 | 52 | -8 | VVVDN |
| 17 |  Alcorcon | 48 | 42 | 13 | 9 | 20 | 32 | 42 | -10 | NDVDV |
| 18 |  Lugo | 47 | 42 | 11 | 14 | 17 | 38 | 53 | -15 | DVNVV |
| 19 |  Sabadell | 46 | 42 | 11 | 13 | 18 | 40 | 48 | -8 | DDDVV |
| 20 |  UD Logroñés | 44 | 42 | 11 | 11 | 20 | 28 | 53 | -25 | DDVDD |
| 21 |  Castellón | 41 | 42 | 11 | 8 | 23 | 35 | 54 | -19 | DDDDD |
| 22 |  Albacete | 38 | 42 | 9 | 11 | 22 | 30 | 53 | -23 | VNNDD |
