Almeria a remporté la Segunda División 2021-22 avec 81 points.
| # | Équipe | Pts | MJ | V | N | D | BP | BC | Diff. | 5 derniers matchs |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  Almeria | 81 | 42 | 24 | 9 | 9 | 68 | 35 | +33 | VVVNN |
| 2 |  Valladolid | 81 | 42 | 24 | 9 | 9 | 71 | 43 | +28 | DVVVV |
| 3 |  Eibar | 80 | 42 | 23 | 11 | 8 | 61 | 45 | +16 | VDVVD |
| 4 |  Las Palmas | 70 | 42 | 19 |
| 13 |
| 10 |
| 57 |
| 47 |
| +10 |
| VVVVV |
| 5 |  Tenerife | 69 | 42 | 20 | 9 | 13 | 53 | 37 | +16 | VVDDD |
| 6 |  Girona | 68 | 42 | 20 | 8 | 14 | 57 | 42 | +15 | VDDVN |
| 7 |  Oviedo | 68 | 42 | 17 | 17 | 8 | 57 | 41 | +16 | VNNDV |
| 8 |  Ponferradina | 63 | 42 | 17 | 12 | 13 | 57 | 55 | +2 | VVDDD |
| 9 |  FC Cartagena | 60 | 42 | 18 | 6 | 18 | 63 | 57 | +6 | DNNVV |
| 10 |  Zaragoza | 56 | 42 | 12 | 20 | 10 | 39 | 46 | -7 | DDNVV |
| 11 |  Burgos | 55 | 42 | 15 | 10 | 17 | 41 | 41 | 0 | DDNVN |
| 12 |  Leganes | 54 | 42 | 13 | 15 | 14 | 50 | 51 | -1 | VNDVN |
| 13 |  Huesca | 54 | 42 | 13 | 15 | 14 | 49 | 44 | +5 | DNDVD |
| 14 |  Mirandes | 52 | 42 | 15 | 7 | 20 | 58 | 62 | -4 | DDVDV |
| 15 |  Ibiza | 52 | 42 | 12 | 16 | 14 | 53 | 59 | -6 | VNDDD |
| 16 |  Lugo | 50 | 42 | 10 | 20 | 12 | 46 | 52 | -6 | DNDDV |
| 17 |  Sporting Gijon | 46 | 42 | 11 | 13 | 18 | 43 | 48 | -5 | DNVND |
| 18 |  Malaga | 45 | 42 | 11 | 12 | 19 | 36 | 57 | -21 | DNVDD |
| 19 |  Amorebieta | 43 | 42 | 9 | 16 | 17 | 44 | 63 | -19 | VDVDV |
| 20 |  Real Sociedad II | 40 | 42 | 10 | 10 | 22 | 43 | 61 | -18 | VVDDD |
| 21 |  Fuenlabrada | 33 | 42 | 6 | 15 | 21 | 39 | 65 | -26 | DDVND |
| 22 |  Alcorcon | 29 | 42 | 6 | 11 | 25 | 37 | 71 | -34 | DVDNV |